Diet quality influences cardiometabolic health, but evidence linking macronutrient ratios to mortality is mixed. In the SUN cohort (19,083 participants, 12.2 y median follow-up), a global MQI showed no significant association with all-cause mortality (HR for highest vs. lowest quartile 0.79, 95% CI 0.59–1.06). Only the carbohydrate quality sub-index was independently associated with lower mortality (HR 0.64 across extreme quartiles, P = 0.021).